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etravirine will lessen the extent or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.Thus the toxicity that benefits in the overdose of fulvestrant has not been d